Endocrine Abstracts

Sorafenib (S) is a reasonably well-tolerated therapy in DTC. A large number of side-effects have been reported. We report our data on the effectiveness and tolerability of S in 6 patients with advanced metastatic epithelial (2 follicular, 1 papillary, 1 insular) and medullary DTCs (52–79 years). In all patients, heart function was evaluated before and during S administration (400 mg/day) together with the objective response rate and changes in serum markers. Underlying he...

Papillary thyroid microcarcinoma (mPTC) is being diagnosed increasingly frequently. Multifocality and nodal involvement are sometimes reported on diagnosis. Management ranges from observation to total thyroidectomy (Tx) followed by radioiodine (RAI) ablation. The role of rhTSH testing in mPTC has not been fully investigated. Torlontano et al. (2006) recently observed that rhTSH-stimulated Tg levels mainly depend on normal tissue remnant. Aim of this study was to further...

Some extra-thyroid effects of TSH have been described in vitro and in vivo. TSH has recently been suggested to induce IL-6 secretion from adipocytes. Leptin is the main secretory protein from adipose tissue. Our aim was to evaluate the acute effect of rhTSH-induced TSH surge on serum leptin levels in differentiated thyroid carcinoma (DTC) patients. Ten patients (2 m, 8 f; age range 31–66 years) with stage 1-3 DTC were evaluated during scheduled standard rhTS...